Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieAutophagy-Induced Neuronal Cell Apoptosis
CeRNA1SNHG3[LncRNA]
miRNAmiR-485[miRNA]
CeRNA2ATG7[mRNA]
Tissue/Cell lineMouse neuroblastoma Neuro-2a (N2a) cells
SpecieMus musculus (mouse)
CitationMetab Brain Dis 2020 Dec 35, 1361-1369 doi:10.1007/s11011-020-00607-1 PMID:32860611
Reference title
LncRNA SNHG3 promotes autophagy-induced neuronal cell apoptosis by acting as a ceRNA for miR-485 to up-regulate ATG7 expression.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc
Functional description
In summary, from our experimental data, it was found thatLncRNA SNHG3 was highly expressed in the mouse modelof the tMCAO and cell model of OGD/R, while miR-485 waslowly expressed, and our further studies had found that theinterference with LncRNA SNHG3 improved brain I/R injuryvia up-regulating miR-485 and down-regulating ATG7 to restrain autophagy and neuronal cell apoptosis. Therefore, thisresearchmight provide new strategies for the treatment ofbrain I/R injury, which was of great significance
Annotations
External Annotation for SNHG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
