Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOral Squamous Cell Cancer
CeRNA1DANCR[LncRNA]
miRNAmiR-216a-5p[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineHuman OSCC cell lines (SCC9,SCC15,SCC25,CAL-27 and Tca8113) and normal human oral keratinocytes (NHOKs)
SpecieHomo sapiens (human)
CitationHum Cell 2020 Oct 33, 1281-1293 doi:10.1007/s13577-020-00411-0 PMID:32860589
Reference title
LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression.
Experimental verification
qRT?PCR,Western blot,Luciferase reporter assay,Flow cytometry assay etc
Functional description
To conclude, our study found the up-regulated DANCR expression and the down-regulated miR-216a-5p expression in OSCC. Thus, DANCR could promote the cell growth, migration and invasion and suppress the cell apoptosis of OSCC cells via targeting miR-216a-5p, which may offer an alternative treatment of OSCC.
Annotations
External Annotation for DANCR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
