Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1MCF2L-AS1[LncRNA]
miRNAmiR-874-3p[miRNA]
CeRNA2FOXM1[mRNA]
Tissue/Cell lineThe human CRC cell lines (HCT116, HT-29, SW620, SW480, LoVo, RKO and DLD1) and normal human colonic epithelial cell line NCM46
SpecieHomo sapiens (human)
CitationCarcinogenesis 2021 Feb 25 42, 263-271 doi:10.1093/carcin/bgaa093 PMID:32860508
Reference title
LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis.
Experimental verification
RT-PCR,Western blot,Luciferase reporter assay etc
Functional description
To sum up, our findings disclosed for the first time that MCF2L-AS1 modulated FOXM1 expression by binding to miR-874-3p, ultimately promoting tumorigenesis, invasiveness and glycolytic metabolism in CRC. We established and characterized a non-canonical MCF2L-AS1/miR-874-3p/FOXM1 crosstalk that regulated tumorigenesis and glycolysis, and highlighted the novel tumor stimulative properties of MCF2L-AS1 in CRC. This sheds a new insight into the regulation mechanism of MCF2L-AS1, and it provides a possible application for the CRC treatment.
Annotations
External Annotation for MCF2L-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
