Basic Information
Regular Relationship :
Tissue/Cell lineH9C2 cells
SpecieHomo sapiens (human)
CitationJ Cell Mol Med 2020 Oct 24, 11500-11511 doi:10.1111/jcmm.15764 PMID:32860492
Reference title
Long non-coding RNA CASC7 is associated with the pathogenesis of heart failure via modulating the expression of miR-30c.
Experimental verification
RT-PCR,Luciferase reporter assay,Western blot etc
Functional description
In summary, the expression of CASC7 was high while the expres-sion of miR-30c was low in plasma and peripheral blood monocytes collected from HF patients. Furthermore, miR-30c can be used as a diagnostic biomarker of HF, while CASC7 is a competing endog-enous RNA of miR-30c. CASC7 can indirectly regulate IL-11 expres-sion via miR-30. The results of this study provided a new perspective for lncRNA-directed diagnosis and treatment of HF.
Annotations
External Annotation for CASC7 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
