Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1SNHG16[LncRNA]
miRNAmiR-124-3p[miRNA]
CeRNA2MCP-1[mRNA]
Tissue/Cell lineHEK293T, FHC cells, and human CRC cell lines SW480,HCT116, DLD-1, and LOVO cells
SpecieHomo sapiens (human)
CitationGene Ther 2020 Aug 28, 10.1038/s41434-020-0176-2 doi:10.1038/s41434-020-0176-2 PMID:32859986
Reference title
LncRNA SNHG16 promotes colorectal cancer cell proliferation, migration, and epithelial-mesenchymal transition through miR-124-3p/MCP-1.
Experimental verification
Western blot,qRT-PCR,Luciferase reporter assay,RIP etc.
Functional description
In conclusion, we highlight the primary role of SNHG16in proliferation, migration, and EMT of CRC cells through miR-124-3p/MCP-1 axis. Ourfindings support the notionthat the development of SNHG16/miR-124-3p/MCP-1 axis-targeted drugs is an effective strategy for treating CRC.
Annotations
External Annotation for SNHG16 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
