Basic Information
Regular Relationship :
Tissue/Cell lineHuman glioma cell lines(U251, A172, U87 and SHG44),human normal glia HEB cells and human umbilical vein endothelial cells (HUVEC)
SpecieHomo sapiens (human)
CitationCell Signal 2020 Nov 75, 109749 doi:10.1016/j.cellsig.2020.109749 PMID:32858123
Reference title
FtMt promotes glioma tumorigenesis and angiogenesis via lncRNA SNHG1/miR-9-5p axis.
Experimental verification
qRT-PCR,Western blot,Flow cytometry assay,Luciferase reporter assay,RIP etc.
Functional description
To sum up, Figure 7shows a schematic representation of the proposed mechanism of FtMtas a novel candidate target for the treatment of glioma.Specifically, FtMtmay serve as a therapeutic agent for glioma treatment based on the finding that FtMt depletion suppresses tumorigenesis and angiogenesis of glioma cell through SNHG1/miR-9-5p axis. Despite the function of FtMt in glioma tumorigenesis and angiogenesis thatare covered in the present study, further investigation is necessary to expound the role and the precise mechanisms whereby FtMt promotethe development of glioma. Anyway, our ultimate goal is to deeply investigate the underlying mechanism and explore thepotential novel strategy for the treatment of glioma.
Annotations
External Annotation for SNHG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
