Basic Information
Regular Relationship :
Tissue/Cell lineHuman neuroblastoma cell lines (SK-N-AS, IMR-32, and Kelly) and human umbilical vascular endothelium cells HUVEC
SpecieHomo sapiens (human)
CitationNeurochem Res 2020 Nov 45, 2679-2690 doi:10.1007/s11064-020-03117-9 PMID:32857295
Reference title
Downregulation of lncRNA XIST Represses Tumor Growth and Boosts Radiosensitivity of Neuroblastoma via Modulation of the miR-375/L1CAM Axis.
Experimental verification
qRT-PCR,Luciferase reporter assay,Western blot etc.
Functional description
In summary, our results proved that XIST silencing repressed tumor growth and enhanced radiosensitivity in NB through regulation of the miR-375/L1CAM axis (Fig. 8). The research highlighted the prospect of XIST as a new target for NB treatment.
Annotations
External Annotation for XIST |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
