Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieThyroid Cancer
CeRNA1GAS5[LncRNA]
miRNAmiR-362-5p[miRNA]
CeRNA2SMG1[mRNA]
Tissue/Cell lineTC cell lines TPC-1 and B-CPAP
SpecieHomo sapiens (human)
CitationIUBMB Life 2020 Nov 72, 2420-2431 doi:10.1002/iub.2365 PMID:32856394
Reference title
LncRNA GAS5 sponges miR-362-5p to promote sensitivity of thyroid cancer cells to (131) I by upregulating SMG1.
Experimental verification
Flow cytometry assay,Luciferase reporter assay,qRT-PCR,Western blot etc.
Functional description
Collectively, we found that GAS5 overexpression coulddownregulate miR-362-5p to inhibit resistance of TC cellsto131I by upregulating SMG1 and inactivating theAkt/mTOR signaling pathway. This study may providenovel targets for TC therapy, while further studies arestill needed to deepen the understanding on detailedmechanisms of TC.
Annotations
External Annotation for GAS5 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
