Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLps-Induced Sepsis
CeRNA1NEAT1[LncRNA]
miRNAmiR-590-3p[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineCardiomyocytes (H9c2 cells)
SpecieHomo sapiens (human)
CitationExp Ther Med 2020 Oct 20, 3290-3300 doi:10.3892/etm.2020.9079 PMID:32855700
Reference title
LncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay,RIP etc.
Functional description
In summary, the present study suggested that NEAT1 plays a promotive role in sepsis progression by sponging miR-590-3p. This is a novel mechanism by which NEAT1 acts on the progression of sepsis. The inhibitory effects of NEAT1 knockdown and miR-590-3p overexpression on LPS-induced cardiomyocyte damage can provide new strategies for the clinical treatment of sepsis. Hence, the discovery of the NEAT1/miR-590-3p axis may contribute to the development of new treatments for sepsis.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
