Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1IGF2-AS[LncRNA]
miRNAmiR-150[miRNA]
CeRNA2IGF2[mRNA]
Tissue/Cell lineNCM-460, CCC-HIE-2, SW620, LoVo, HT29, HCT116, HCT8, DLD1and 293 T cell
SpecieHomo sapiens (human)
CitationPathol Res Pract 2020 Oct 216, 153104 doi:10.1016/j.prp.2020.153104 PMID:32853944
Reference title
Comprehensive ceRNA network analysis and experimental studies identify an IGF2-AS/miR-150/IGF2 regulatory axis in colorectal cancer.
Experimental verification
qPCR,luciferase reporter assay,RNA-seq etc.
Functional description
In summary, we successfully built ceRNA regulatory networks toprovide a comprehensive understanding of detailed molecular me-chanisms underlying the pathogenesis of CRC using two independentdatasets. Importantly, we confirmed a potential regulatory axis thatIGF2-AS could regulate the expression of IGF2 by sponging miR-150that was validated in both CRC cell lines and clinical samples. Wesuppose that the IGF2-AS/miR-150/IGF2 axis may exert a critical rolein the development and progression of CRC.
Annotations
External Annotation for IGF2-AS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
