Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieMalignant Phenotype In Bone Marrow Mesenchymal Stem Cells
CeRNA1FTX[LncRNA]
miRNAmiR-186[miRNA]
CeRNA2c-Met[mRNA]
Tissue/Cell lineNormal BMSCs and malignantly transformed BMSCs
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2020 Nov 131, 110666 doi:10.1016/j.biopha.2020.110666 PMID:32853911
Reference title
The long noncoding RNA FTX promotes a malignant phenotype in bone marrow mesenchymal stem cells via the miR-186/c-Met axis.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay etc..
Functional description
Our study showed that BMSCs were malignantly transformed by GSCs in a dual-colour fluorescent tumour model. Moreover, lncRNA-FTX was found to promote the proliferation, migration and invasion of tBMSCs by sponging miR-186 and functionally upregulating c-Met expression. Our findings provide a new perspective in that lncRNA-FTX/ miR-186/c-Met is involved in glioma progression, and this axis may serve as a new target for the treatment of glioma
Annotations
External Annotation for FTX |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
