Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBreast Cancer
CeRNA1LINC01705[LncRNA]
miRNAmiR-186-5p[miRNA]
CeRNA2TPR[mRNA]
Tissue/Cell lineThe human normal mammary epithelial cell line MCF 10A and the breast cancer cell lines CAL-51, MCF-7, BT-20, BT-549, and AU565
SpecieHomo sapiens (human)
CitationFront Genet 2020 11, 779 doi:10.3389/fgene.2020.00779 PMID:32849791
Reference title
The Long Non-coding RNA LINC01705 Regulates the Development of Breast Cancer by Sponging miR-186-5p to Mediate TPR Expression as a Competitive Endogenous RNA.
Experimental verification
qRT-PCR,RIP,luciferase reporter assay,Western blot etc.
Functional description
In summary, LINC01705 acts as a competitive endogenous RNA to regulate TPR expression via sponging miR-186-5p, thereby regulating the progression of breast cancer.
Annotations
External Annotation for LINC01705 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
