Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1TMPO-AS1[LncRNA]
miRNAhsa-let-7a-5p[miRNA]
CeRNA2SLC12A7[mRNA]
Tissue/Cell lineNA
SpecieHomo sapiens (human)
CitationFront Pharmacol 2020 11, 1112 doi:10.3389/fphar.2020.01112 PMID:32848739
Reference title
Construction and Analysis of the Tumor-Specific mRNA-miRNA-lncRNA Network in Gastric Cancer.
Experimental verification
RNA-seq,Microarray etc.
Functional description
In summary, we identified a survival-related gene-based ceRNA network using the WGCNA algorithm, and the constructed lncRNA–miRNA–mRNA ceRNA interactive network will probably provide a basis for additional inspection of the regulatory mechanisms of gastric cancer. Gastric cancer has high heterogeneity among its different histological and molecular subtypes. Thus, while we have selected the expression profiles with the largest sample size that we could obtain currently, we must admit that further experimental works and large cohorts are needed to verify our results and elucidate the prognostic value of ceRNA networks in gastric cancer.
Annotations
External Annotation for TMPO-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
