Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1TUG1[LncRNA]
miRNAmiR-455-3p[miRNA]
CeRNA2HK2[mRNA]
Tissue/Cell lineHepatoma samples
SpecieHomo sapiens (human)
CitationHepatology 2018 Jan 67, 188-203 doi:10.1002/hep.29462 PMID:28802060
Reference title
Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma
Experimental verification
qRT-PCR,Western blot etc.
Functional description
In conclusion, we have made a conceptual progress supporting the theory that altered glycolytic metabolism contributes to metastatic phenotypes. TUG1 reduced p21 expression through upregulation of EED expression and led to decrease p21-E2F1 interaction and enhance miR-455-3p expression. Consequently, miR-455-3p repressed AMPKβ2 expression and contribute to increase HK2 and Snail expression. We have identified a novel pathway interlinking TUG1, miR-455-3p, AMPKβ2, AMPKα/mTOR, Snail and HK2, which regulates glycolysis, motility, and invasion of hepatoma cells. Our study provides the potential therapeutic strategies of targeting TUG1 and HK2 for the treatment of HCC.
Annotations
External Annotation for TUG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
