Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1HOTAIR[LncRNA]
miRNAmiR-23b-3p[miRNA]
CeRNA2ZEB1[mRNA]
Tissue/Cell lineHCC cell lines Huh7, Hep3B, HepG2, MHCC97H and normal hepatic cells L-02
SpecieHomo sapiens (human)
CitationGene 2018 Sep 5 670, 114-122 doi:10.1016/j.gene.2018.05.061 PMID:29778425
Reference title
LncRNA HOTAIR contributes to the malignancy of hepatocellular carcinoma by enhancing epithelial-mesenchymal transition via sponging miR-23b-3p from ZEB1
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc..
Functional description
In conclusion, our present study found that HOTAIR was overexpressed in HCC tissues and cell lines and promoted invas ion and migration of HCC cells by enhanc ing EMT. H igh leve l of HOTAIR inhibited the expression of miR-23b-3p but benefit to the production of ZEB1. HOTAIR promoted metastasis in HCC by enhancing EMT via sponging miR-23b-3p from ZEB1 both in vitroand in vivo. The HOTAIR-miR-23b-3p-ZEB1 axis may provide a new perspective for treatment of HCC.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
