Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1MEG3[LncRNA]
miRNAmiR-483-3p[miRNA]
CeRNA2ERp29[mRNA]
Tissue/Cell lineThe HCC cell lines HepG2 and Human Embryonic Kidney (HEK)293T cell
SpecieHomo sapiens (human)
CitationLife Sci 2019 Sep 1 232, 116602 doi:10.1016/j.lfs.2019.116602 PMID:31251997
Reference title
High glucose regulates ERp29 in hepatocellular carcinoma by LncRNA MEG3-miRNA 483-3p pathway.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc..
Functional description
Our study established a role for regulatory pathway of MEG3/miR-483-3p/ ERp29 in HCC under the conditions of high glucose. Overall, our findings suggest that HG negatively regulates the expression of ERp29 by inhibiting the miRNA sponge role of MEG3 on miR-483-3p in HCC cells.
Annotations
External Annotation for MEG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
