Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1MEG3[LncRNA]
miRNAmiR-9-5p[miRNA]
CeRNA2SOX11[mRNA]
Tissue/Cell lineHuman embryonic kidney cell line (293T) and Human HCC cell lines (SK-HEP-1 and Huh7)
SpecieHomo sapiens (human)
CitationBraz J Med Biol Res 2019 52, e8631 doi:10.1590/1414-431x20198631 PMID:31531526
Reference title
lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11
Experimental verification
qRT-PCR,Western blot,Flow cytometry etc.
Functional description
In the present study, we determined the expression of MEG3, miR-9-5p, and SOX11 in HCC tissues, and explored their interactions in HCC. Furthermore, we detected the effect of these molecules on HCC cell growth and apoptosis.
Annotations
External Annotation for MEG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
