Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1MEG3[LncRNA]
miRNAmiR-10a-5p[miRNA]
CeRNA2PTEN[mRNA]
Tissue/Cell lineThe HepG2 HCC cell line
SpecieHomo sapiens (human)
CitationAm J Transl Res 2019 11, 4089-4099, PMID:31396320
Reference title
LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies
Experimental verification
RT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
The results of this study confirmed that overexpression of lncRNA MEG3 leads to the inhibition of miRNA-10a-5p expression and the PTEN/AKT/Bcl-2/Bax/p53 and PTEN/AKT/MMP-2/9 signaling pathways. Thus, the biology of lncRNA MEG3 in HCC merits further study to evaluate its potential to serve as a therapeutic target for HCC.
Annotations
External Annotation for MEG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
