Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1NEAT1[LncRNA]
miRNAmiR-155[miRNA]
CeRNA2Tim-3[mRNA]
Tissue/Cell lineCD8+T cells
SpecieHomo sapiens (human)
CitationInt J Biochem Cell Biol 2019 May 110, 1-8 doi:10.1016/j.biocel.2019.01.019 PMID:30710754
Reference title
Repression of lncRNA NEAT1 enhances the antitumor activity of CD8+T cells against hepatocellular carcinoma via regulating miR-155/Tim-3.
Experimental verification
Western blot,qRT-PCR,Flow cytometry,RIP etc.
Functional description
Viamodulating the miR-155/Tim-3 pathway, repression of NEAT1 restrained CD8+Tcell apoptosis and enhanced the cytolysis activityagainst HCC, implyingan effective target for improving the outcome of immunotherapy.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
