Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1HULC[LncRNA]
miRNAmiR-6886-3p[miRNA]
CeRNA2USP22[mRNA]
Tissue/Cell lineHuman HCC cell lines including HepG2, Hep3B, PLC, Huh7, smmc7721 andhepatic cell line L02
SpecieHomo sapiens (human)
CitationOncogene 2017 Jun 22 36, 3528-3540 doi:10.1038/onc.2016.521 PMID:28166203
Reference title
LncRNA HULC triggers autophagy via stabilizing Sirt1 andattenuates the chemosensitivity of HCC cells
Experimental verification
qRT-PCR,qRT-PCR,Western blot,microarray etc.
Functional description
In summary, we revealed in this study that HULC decreases theexpression and activities of the three miRNAs (miR-6825-5p,miR-6845-5p and miR-6886-3p), elevates the level of USP22protein, enhances the deubiquitination of Sirt1 and stabilizes it,which ultimately triggers the autophagy of HCC cells. Furthermore,the HULC/Sirt1/autophagy pathway is activated in the presence ofchemotherapeutic reagents, and interference of the pathwayenhances the chemosensitivity of HCC cells. Altogether, thesefindings illustrate a new function of HULC and the‘HULC/USP22/Sirt1/protective autophagy’pathway may serves as a novel targetfor developing sensitizing strategy to HCC chemotherapy
Annotations
External Annotation for HULC |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
