Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1DANCR[LncRNA]
miRNAmiR-214[miRNA]
CeRNA2CTNNB1[mRNA]
Tissue/Cell lineHCCLM3 cells
SpecieHomo sapiens (human)
CitationHepatology 2016 Feb 63, 499-511 doi:10.1002/hep.27893 PMID:25964079
Reference title
Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1
Experimental verification
etc.
Functional description
We speculate that there can be a novel regulatory transcript-mediated release of targeted transcripts (CTNNB1 here) from miRNA repression (by lncRNA and mRNA DANCRhere), which would add the known crosstalk between established pathways.
Annotations
External Annotation for DANCR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
