Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1ANRIL[LncRNA]
miRNAmiR-384[miRNA]
CeRNA2STAT3[mRNA]
Tissue/Cell lineSMCC7721, HepG2, MHCC-97H, SNU-449, HUH-7, LO2 and HEK-293T cells
SpecieHomo sapiens (human)
CitationJ Environ Pathol Toxicol Oncol 2019 38, 119-131 doi:10.1615/JEnvironPatholToxicolOncol.2019028282 PMID:31679275
Reference title
Evaluation of LncRNA ANRIL Potential in Hepatic Cancer Progression
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay,RIP etc.
Functional description
ANRIL is involved in HCC progression by direct targeting of miR-384 and STAT3. Also, ANRIL could act as a potential candidate for HCC diagnosis, prognosis, and therapy.
Annotations
External Annotation for ANRIL |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
