Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1ANRIL[LncRNA]
miRNAmiR-144[miRNA]
CeRNA2PBX3[mRNA]
Tissue/Cell lineHuman HCC cell lines MHCC97 and Li-7
SpecieHomo sapiens (human)
CitationAnticancer Drugs 2019 Nov 30, 1013-1021 doi:10.1097/cad.0000000000000807 PMID:31609763
Reference title
LncRNA ANRIL promotes cell growth, migration and invasion of hepatocellular carcinoma cells via sponging miR-144. Anticancer Drugs.
Experimental verification
qRT-PCR,Luciferase reporter assay,Western blot etc.
Functional description
In summary, our data demonstrated that ANRIL pro-moted HCC cells growth, migration and invasion. One of possible mechanisms responsible for the tumour-pro-moting actions is that ANRIL sponging miR-144 to derepress PBX3. Furthermore, miR-144 blocked PI3K/AKT and JAK/STAT signalling pathways by targeting PBX3.
Annotations
External Annotation for ANRIL |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
