Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1GAS5[LncRNA]
miRNAmiR-21[miRNA]
CeRNA2PTEN[mRNA]
Tissue/Cell lineThree HCC cell lines (Bel-7402, SMMC-7721, andHCCLM3) and a normal liver cell line (L-02) wer
SpecieHomo sapiens (human)
CitationTumour Biol 2016 Feb 37, 2691-702 doi:10.1007/s13277-015-4111-x PMID:26404135
Reference title
Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21.
Experimental verification
Western blot,qRT-PCR,RNAi etc.
Functional description
Thus, GAS5 acts as a tumor suppressor in HCCs throughnegative regulation of miR-21 and its targets and proteinsabout migration and invasion in cancer cells, which may bea target for treating HCC.
Annotations
External Annotation for GAS5 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
