Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieMyocardial Ischamia Reperfusion Injury Injury
CeRNA1TALNEC2[LncRNA]
miRNAmiR-21[miRNA]
CeRNA2PDCD4[mRNA]
Tissue/Cell lineThe cardiomyocytes cell line H9c2
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2019 Aug 120, 12912-12923 doi:10.1002/jcb.28562 PMID:30861181
Reference title
Long noncoding RNA TALNEC2 regulates myocardial ischemic injury in H9c2 cells by regulating miR-21/PDCD4-medited activation of Wnt/β-catenin pathway.
Experimental verification
qRT-PCR,Western blot etc.
Functional description
In conclusion, our findings reveal that overexpressionof TALNEC2 may aggravate hypoxia injury in H9c2 cellsvia regulating miR-21/PDCD4-medited activation of theWnt/β-catenin pathway. TALNEC2 may serve as apromising therapeutic target in myocardial ischemia.However, clinical and in vivo studies in myocardialischemia were not performed in this study. More studiesare still needed to confirm our findings.
Annotations
External Annotation for TALNEC2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
