Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePre-Eclampsia
CeRNA1Linc00261[LncRNA]
miRNAmiR-558[miRNA]
CeRNA2TIMP4[mRNA]
Tissue/Cell lineThe human trophoblast cell line (HTR-8/SVneo cells)
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2019 Aug 120, 13243-13253 doi:10.1002/jcb.28598 PMID:30891826
Reference title
Upregulated long noncoding RNA Linc00261 in pre-eclampsia and its effect on trophoblast invasion and migration via regulating miR-558/TIMP4 signaling pathway.
Experimental verification
qRT-PCR,Flow cytometry,Western blot, Luciferase reporter assay etc.
Functional description
In conclusion, our results for the first time showed theupregulation of Linc00261 in the placental tissues ofsevere PE patients. The mechanistic results indicated thatLinc00261 exerted the suppressive effects on the tropho-blast invasion and migration via targeting miR-558/TIMP4axis, which may involve in the pathogenesis of PE.
Annotations
External Annotation for Linc00261 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
