Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLaryngocarcinoma
CeRNA1TUG1[LncRNA]
miRNAmiR-145-5p[miRNA]
CeRNA2ROCK1[mRNA]
Tissue/Cell lineLaryngocarcinoma cell lines SNU46, SNU899 and UM-SCC-10B
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2019 Aug 120, 13392-13402 doi:10.1002/jcb.28614 PMID:30916820
Reference title
Upregulation of long noncoding RNA TUG1 contributes to the development of laryngocarcinoma by targeting miR-145-5p/ROCK1 axis.
Experimental verification
qRT-PCR,Western blot etc.
Functional description
To sum up, our study firstly demonstrated that TUG1was upregulated in laryngocarcinoma, and TUG1 wasinvolved in the development oflaryngocarcinoma throughsuppressing miR-145-5p to activate the RhoA/ROCK/MMPs signaling. Therefore, TUG1 may push a utility inclinical applications for the treatment of laryngocarcinoma
Annotations
External Annotation for TUG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
