Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLiver Cancer
CeRNA1HOXA11-AS[LncRNA]
miRNAmiR-15a-3p[miRNA]
CeRNA2STAT3[mRNA]
Tissue/Cell lineLiver cancer cell lines (hepatocellular carcinoma,CSQT-2, and HCCLM3; hepatoblastoma, Huh-6) andnormal liver cell line L02
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2019 Sep 120, 15941-15951 doi:10.1002/jcb.28871 PMID:31099097
Reference title
HOXA11-AS regulates JAK-STAT pathway by miR-15a-3p/STAT3 axis to promote the growth and metastasis in liver cancer.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
Our study suggested that HOAX11-AS could regulate the JAK-STATsignaling pathway by miR-15a-3p/STAT3 axis to promote the progression of livercancer. Thus, HOXA11-AS may be regarded as an effective biomarker withdiagnostic, prognostic, and therapeutic potentials for liver cancer.
Annotations
External Annotation for HOXA11-AS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
