Basic Information
Regular Relationship :
Tissue/Cell lineThe normal human ovarian surface epithelial cells (HOSEPiCs) and human ovarian cancer cells (cisplatin-sensitivestrain SKOV3 and cisplatin-resistant strain SKOV3/DDP)
SpecieHomo sapiens (human)
CitationBiosci Rep 2019 Jul 31 39 doi:10.1042/bsr20182101 PMID:31189742
Reference title
LncRNA ANRIL affects the sensitivity of ovarian cancer to cisplatin via regulation of let-7a/HMGA2 axis.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
In summary, our study found the up-expression of ANRIL in ovarian cancer tissues and drug-resistant cells, andsilencing ANRIL could increase let-7a to further reduce HMGA2, which can promote the apoptosis and improvethe cisplatin sensitivity of ovarian cancer cells. Therefore, this strategy provides an alternative therapeutic target forconquering cisplatin-resistance in ovarian cancer.
Annotations
External Annotation for ANRIL |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
