Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieClear Cell Renal Cancer
CeRNA1ADAMTS9-AS2[LncRNA]
miRNAmiR-27a-3p[miRNA]
CeRNA2FOXO1[mRNA]
Tissue/Cell lineThree ccRCC cell lines (786-O, caki-1 and 769-P) and normal renal proximal tubular epithelial cell lines (HKC, HK-2)
SpecieHomo sapiens (human)
CitationAging (Albany NY) 2019 Aug 10 11, 5705-5725 doi:10.18632/aging.102154 PMID:31400752
Reference title
LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis.
Experimental verification
qRT-PCR,Western blot,RIP,Luciferase reporter assay etc.
Functional description
In summary, an inhibitory role of ADAMTS9-AS2 in the proliferation and its lessened role in the chemoresistance was revealed in ccRCC. In addition, the ADAMTS9-AS2 - miR-27a-3p - FOXO1 axis was identified as an aspect of the underlying mechanism. Future research should consider the functional role of FOXO1 in chemoresistance and the concrete mechanism of ADAMTS9-AS2 (such as the phosphoinositide 3-kinase/Akt pathway) in the pathogenesis of ccRCC.
Annotations
External Annotation for ADAMTS9-AS2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
