Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1HOTAIR[LncRNA]
miRNAmiR-126[miRNA]
CeRNA2CXCR4[mRNA]
Tissue/Cell lineHuman gastric mucosal epithelial cell line GES-1, gastric cancer cell lines SNU-216, AGS, SGC-7901 and BGC-823 cells
SpecieHomo sapiens (human)
CitationCancer Med 2019 Nov 8, 6768-6779 doi:10.1002/cam4.1302 PMID:31517442
Reference title
lncRNA HOTAIR promotes gastric cancer proliferation and metastasis via targeting miR-126 to active CXCR4 and RhoA signaling pathway.
Experimental verification
RT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
In conclusion, our study identified the critical role of lncRNA HOTAIR/miR-126/CXCR4/RhoA axis as in gastric cancer, providing a new thought for the targeted therapy of gastric cancer.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
