Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBreast Cancer
CeRNA1LINC02582[LncRNA]
miRNAmiR-200c[miRNA]
CeRNA2CHK1[mRNA]
Tissue/Cell lineMDA-MB-231, MCF-7, BT549, SKBR3, T47D, and BT474cell
SpecieHomo sapiens (human)
CitationCell Death Dis 2019 Oct 10 10, 764 doi:10.1038/s41419-019-1996-0 PMID:31601781
Reference title
Long noncoding RNA LINC02582 acts downstream of miR-200c to promote radioresistance through CHK1 in breast cancer cells.
Experimental verification
Western blot,RNAi,Microarray,qRT-PCR,Luciferase reporter assay etc.
Functional description
In summary, we demonstrated thatLINC02582is adownstream target of miR-200c.LINC02582is requiredfor radioresistance in breast cancer cells. Mechanistically,LINC02582interacts with USP7 to deubiquitinate andstabilize CHK1, thus promoting radioresistance. Ourresults suggested that the miR-200c/LINC02582/USP7/CHK1 signaling axis is a potential target to improve theresponse of breast cancer to radiation therapy
Annotations
External Annotation for LINC02582 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
