Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieMelanoma
CeRNA1LINC00518[LncRNA]
miRNAmiR-204-5p[miRNA]
CeRNA2AP1S2[mRNA]
Tissue/Cell lineThe human malignant melanoma cell lines A375, A2058and SK-MEL-28
SpecieHomo sapiens (human)
CitationCell Death Dis 2019 Nov 11 10, 855 doi:10.1038/s41419-019-2090-3 PMID:31712557
Reference title
Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay,FISH etc.
Functional description
In conclusion, we demonstrated that LINC00518 plays akey role in the malignant progression of melanoma.LINC00518 facilitates melanoma metastasis by spongingmiR-204-5p to release AP1S2 mRNA transcripts targetedby miR-204-5p, thereby promoting the AP1S2 expression.Studying the molecular mechanism of LINC00518 inmelanoma is of great significance to improve the under-standing of the molecular biological basis of melanomadevelopment and identify new therapeutic targets formelanoma patients.
Annotations
External Annotation for LINC00518 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
