Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBladder Cancer
CeRNA1NNT-AS1[LncRNA]
miRNAmiR-1301-3p[miRNA]
CeRNA2PODXL[mRNA]
Tissue/Cell lineFour bladder cancer cell lines (RT-4, UM-UC-3, J82, andT24) and human urothelial cell line, SV-HUC-1
SpecieHomo sapiens (human)
CitationNeurourol Urodyn 2020 Feb 39, 547-557 doi:10.1002/nau.24238 PMID:31782983
Reference title
NNT-AS1 enhances bladder cancer cell growth by targeting miR-1301-3p/PODXL axis and activating Wnt pathway.
Experimental verification
qRT-PCR,Flow cytometry,RNAi,Luciferase reporter assay etc.
Functional description
In conclusion, NNT-AS1 played a carcinogenic role inBC cell growth and enhanced BC cell growth by targetingmiR-1301-3p/PODXL axis and activating the Wnt path-way, which provides a helpful revelation for investigatingthe potential therapeutic methods for patients with BC.
Annotations
External Annotation for NNT-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
