Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieUveal Melanoma
CeRNA1MALAT1[LncRNA]
miRNAmiR-608[miRNA]
CeRNA2HOXC4[mRNA]
Tissue/Cell lineUveal melanoma cell lines MUM-2B, C918 and M619 and a retinal pigment epithelial (RPE) cell line
SpecieHomo sapiens (human)
CitationAm J Physiol Cell Physiol 2020 May 1 318, C903-c912 doi:10.1152/ajpcell.00262.2019 PMID:31913701
Reference title
Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4.
Experimental verification
Western blot,Flow cytometry etc.
Functional description
Taken together, MALAT1 down-regulation may inhibit the proliferation, migration and invasion of uveal melanoma cells via miR-608-dependent downregulation of HOXC4.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
