Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1FOXD3-AS1[LncRNA]
miRNAmiR-127-3p[miRNA]
CeRNA2MDM2[mRNA]
Tissue/Cell lineNormal human lung bronchial epithelial cells (NHBE) and NSCLC cell lines (A549 and H1299)
SpecieHomo sapiens (human)
CitationCancer Cell Int 2020 20, 350 doi:10.1186/s12935-020-01402-9 PMID:32742197
Reference title
LncRNA FOXD3-AS1 promoted chemo-resistance of NSCLC cells via directly acting on miR-127-3p/MDM2 axis.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
In conclusion, our study demonstrated the pivotal roles of FOXD3-AS1/miR-127-3p/MDM2 regulatory signaling pathways in cisplatin resistance of NSCLC cells (Fig. 7). The present study may provide new insights into overcoming cisplatin resistance in NSCLC treatment.
Annotations
External Annotation for FOXD3-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
