Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieAge-Related Cataract
CeRNA1MIAT[LncRNA]
miRNAmiR-181a[miRNA]
CeRNA2ERK[mRNA]
Tissue/Cell lineThe human LEC line SRA01/04
SpecieHomo sapiens (human)
CitationExp Ther Med 2020 Aug 20, 1053-1063 doi:10.3892/etm.2020.8749 PMID:32742346
Reference title
lncRNA MIAT increases cell viability, migration, EMT and ECM production in age-related cataracts by regulating the miR-181a/CTGF/ERK signaling pathway.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
To conclude, MIAT and CTGF expression were increased, while miR-181a was decreased in ARC tissues and TGF-β2-treated SRA01/04 cells.
Annotations
External Annotation for MIAT |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
