Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma Bone Metastasis
CeRNA1LncZEB1-AS1[LncRNA]
miRNAmiR-302b[miRNA]
CeRNA2AKT[mRNA]
Tissue/Cell lineHuman HCC (PLC, MHCC-97H, Hep3B, and Huh7) and control (NCM-460) cell lines
SpecieHomo sapiens (human)
CitationJ Cancer 2020 11, 5118-5128 doi:10.7150/jca.45995 PMID:32742459
Reference title
LncZEB1-AS1 regulates hepatocellular carcinoma bone metastasis via regulation of the miR-302b-EGFR-PI3K-AKT axis.
Experimental verification
qRT-PCR,RIP,luciferase reporter assay,Western blot etc.
Functional description
In summary, we have provided novel evidence suggesting that lncZEB1-AS1 is an important regulator of HCC BM. We have additionally highlighted a previously undescribed lncZEB1-AS1-miR-302b-EGFR-PI3K-AKT signaling axis that may govern this metastatic process. This axis may be a viable target for therapeutic intervention in HCC patients as a means of significantly improving quality of life and extending patient survival.
Annotations
External Annotation for LncZEB1-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
