Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1ADIPOQ[LncRNA]
miRNAmiR-219c-3p[miRNA]
CeRNA2TP53[mRNA]
Tissue/Cell lineHuman colorectal cancer cells Caco-2 cells
SpecieHomo sapiens (human)
CitationEur Rev Med Pharmacol Sci 2020 Jul 24, 7645-7654 doi:10.26355/eurrev_202007_22265 PMID:32744690
Reference title
Decreased long noncoding RNA ADIPOQ promoted cell proliferation and metastasis via miR-219c-3p/TP53 pathway in colorectal carcinoma.
Experimental verification
qRT-PCR,Luciferase reporter assay,etc..
Functional description
CONCLUSIONS: For the first time, we found that lncRNA-ADIPOQ was downregulated in hu-man colorectal cancer cells, which could facili-tate tumor proliferation, migration and invasion as a ceRNA by sponging with miR-219c-3p
Annotations
External Annotation for ADIPOQ |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
