Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEndometrial Cancer
CeRNA1Lnc-OC1[LncRNA]
miRNAmiR-34a[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineThe EC cell lines (Ishikawa)
SpecieHomo sapiens (human)
CitationReprod Sci 2020 Oct 27, 1848-1856 doi:10.1007/s43032-020-00202-w PMID:32748220
Reference title
Inhibition of Lnc-OC1 Induced Cell Apoptosis and Decreased Cell Viability by Releasing miR-34a and Inhibiting PD-L1 in Endometrial Carcinoma.
Experimental verification
MicroRNA,qRT-PCR,Luciferase reporter assay,Western blot,etc..
Functional description
In conclusion, we proved that Lnc-OC1/miR-34a/PD-L1axis played a crucial role in inhibiting endometrial carcinomacell growth in this work. Treatments that target Lnc-OC1might benefit for remitting EC and fighting drug resistance.
Annotations
External Annotation for Lnc-OC1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
