Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1SLC16A1-AS1[LncRNA]
miRNAmiR-301b-3p[miRNA]
CeRNA2CHD5[mRNA]
Tissue/Cell lineHCC cell lines (Huh7, SMCC-7721, HepG2 and MHCC-97H) and normal human liver LO2 cells wer
SpecieHomo sapiens (human)
CitationEnviron Sci Pollut Res Int 2020 Dec 27, 42778-42790 doi:10.1007/s11356-020-09998-1 PMID:32748357
Reference title
SLC16A1-AS1 enhances radiosensitivity and represses cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay,RIP etc.
Functional description
This study probed into the association between SLC16A1-AS1 and HCC. Our data demonstrated that SLC16A1-AS1suppressed HCC cellular processes as well as enhanced radio-sensitivity by targeting the miR-301b-3p/CHD5 axis, whichmay offer a new perspective into for HCC therapy
Annotations
External Annotation for SLC16A1-AS1 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
