Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieTongue Squamous Cell Carcinoma
CeRNA1UCA1[LncRNA]
miRNAmiR-138-5p[miRNA]
CeRNA2CCR7[mRNA]
Tissue/Cell lineTSCC cell lines (SCC4, SCC15, SCC25 and CAL-27)
SpecieHomo sapiens (human)
CitationNeoplasma 2020 Nov 67, 1256-1265 doi:10.4149/neo_2020_191119N1187 PMID:32749849
Reference title
Long noncoding RNA UCA1 regulates CCR7 expression to promote tongue squamous cell carcinoma progression by sponging miR-138-5p.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay etc.
Functional description
In summary, we concluded that UCA1 played an oncogenic role in TSCC through regulating the miR-138-5p/CCR7 axis, which provided a reliable biomarker for the clinical treatment of TSCC.
Annotations
External Annotation for UCA1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
