Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOsteosarcoma
CeRNA1LINC01535[LncRNA]
miRNAmiR-214-3p[miRNA]
CeRNA2KCNC4[mRNA]
Tissue/Cell lineHuman OS cell lines (MG63, Saos2, HOS, U2OS) andhuman osteoblasts (hFOB1.19)
SpecieHomo sapiens (human)
CitationCancer Manag Res 2020 12, 5575-5585 doi:10.2147/cmar.S232757 PMID:32753970
Reference title
LINC01535 Promotes the Development of Osteosarcoma Through Modulating miR-214-3p/KCNC4 Axis.
Experimental verification
Western blot,RIP,FISH,Luciferase reporter assay etc.
Functional description
LINC01535, miR-214-3p and KCNC4 constituted an effective axis thatexerted a pregnant regulation in OS development, which is a quite meaningful discoveryfor exploring potential therapeutic methods for OS patients.
Annotations
External Annotation for LINC01535 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
