LncACTdb 3.0

miRNA

miR-31[miRNA]

CeRNA2

RDX[mRNA]

Tissue/Cell line

Breast Cells, Hek293T Cells

Specie

Mus musculus (mouse)

Citation

Cell 2009 Jun 12 137, 1032-46 doi:10.1016/j.cell.2009.03.047 PMID:19524507

Reference title

A pleiotropically acting microRNA, miR-35, inhibits breast cancer metastasis

Experimental verification

Luciferase reporter assay;qRT-PCR;Western blot

Functional description

We deploy a stable microRNA sponge strategy to inhibit miR-35 in vivo; this allows otherwise-nonaggressive breast cancer cells to metastasize.

External Annotation for mir-31 sponge
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)