Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1LINC01123[LncRNA]
miRNAmiR-34a-5p[miRNA]
CeRNA2TUFT1[mRNA]
Tissue/Cell lineThree human HCC cell lines (HepG2, Huh7 and Hep3B) and a normal human liver cell line (LO2)
SpecieHomo sapiens (human)
CitationInt J Biol Sci 2020 16, 2296-2305 doi:10.7150/ijbs.45457 PMID:32760198
Reference title
Long noncoding RNA LINC01123 promotes the proliferation and invasion of hepatocellular carcinoma cells by modulating the miR-34a-5p/TUFT1 axis.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay,RIP etc.
Functional description
In conclusion, we found that LINC01123 is an oncogene in HCC. The upregulated expression of LINC01123 in HCC tissues may potentially predict poor prognosis. LINC01123 accelerated HCC cell proliferation, migration and invasion by sponging miR-34a-5p and enhancing TUFT1 expression. This study may provide new insight into the pathogenesis of HCC.
Annotations
External Annotation for LINC01123 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
