Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1SLCO4A1-AS1[LncRNA]
miRNAmiR-4701-5p[miRNA]
CeRNA2NFE2L1[mRNA]
Tissue/Cell lineLUAD cell lines (PC-9, Calu3, A549, and HCC827) and human normal lung epithelial cell (BEAS-2B)
SpecieHomo sapiens (human)
CitationCancer Med 2020 Oct 9, 7205-7217 doi:10.1002/cam4.3270 PMID:32762035
Reference title
SLCO4A1-AS1 promotes cell growth and induces resistance in lung adenocarcinoma y modulating miR-4701-5p/NFE2L1 axis to activate WNT pathway.
Experimental verification
qRT-PCR,FISH,RIP,Western blot,luciferase reporter assay etc.
Functional description
In conclusion, this study revealed a novel highly expressed lncRNA SLCO4A1-AS1 in LUAD. SLCO4A1-AS1 pro-moted cell growth and inhibited chemosensitivity in LUAD via miR-4701-5p/NFE2L1 axis to stimulate WNT pathway, which might be helpful for deciphering novel therapeutic methods for LUAD patients.
Annotations
External Annotation for SLCO4A1-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
