LncACTdb 3.0

miRNA

CeRNA2

RORA[mRNA]

Tissue/Cell line

Human periodontal ligament cells (hPDLCs)

Specie

Homo sapiens (human)

Citation

Oral Dis 2021 Apr 27, 600-610 doi:10.1111/odi.13590 PMID:32762066

Reference title

Long non-coding RNA TUG1 participates in LPS-induced periodontitis by regulating miR-498/RORA pathway.

Experimental verification

qRT-PCR,Western blot,luciferase reporter assay etc.

Functional description

Conclusion: Therefore, TUG1 could protect against periodontitis via regulating miR-498/RORA mediated Wnt/Î²-catenin signaling.

External Annotation for TUG1
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)