Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOral Squamous Cell Cancer
CeRNA1HOXC13-AS[LncRNA]
miRNAmiR-378g[miRNA]
CeRNA2HOXC13[mRNA]
Tissue/Cell lineNormal oral keratinocytes (NHOK) and OSCC cells (Fadu, TSCCA,HSU3, SCC15)
SpecieHomo sapiens (human)
CitationOral Oncol 2020 Dec 111, 104946 doi:10.1016/j.oraloncology.2020.104946 PMID:32763778
Reference title
HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay,RIP,FISH etc.
Functional description
In conclusion, our studyfirstly showed that HOXC13-AS functionedas a ceRNA to accelerate the malignancy in OSCC via miR-378g/HOXC13 axis, providing new thoughts for improving the lncRNA-tar-geted treatment of OSCC
Annotations
External Annotation for HOXC13-AS |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
