Basic Information
Regular Relationship :
Tissue/Cell lineHuman lymphoma cell lines Daudi and Namalwa
SpecieHomo sapiens (human)
CitationCancer Manag Res 2020 12, 5845-5855 doi:10.2147/cmar.S248698 PMID:32765087
Reference title
Knockdown of lncRNA MCM3AP-AS1 Attenuates Chemoresistance of Burkitt Lymphoma to Doxorubicin Treatment via Targeting the miR-15a/EIF4E Axis.
Experimental verification
Flow Cytometry,luciferase reporter assay,Western blot etc.
Functional description
This study identified a novel lncRNA, MCM3AP-AS1, that was upregulated in Burkitt lymphoma tissues and indicated poor prognosis. Knockdown of MCM3AP-AS1 increased drug sensitivity, enhanced cell cycle progression and facilitated apoptosis by regulating EIF4E and its downstream anti-apoptotic proteins in vitro and in vivo. MiR-15a functioned as the link between MCM3AP-AS1 and EIF4E. Therefore, targeting the MCM3AP-AS1/miR-15a/EIF4E axis might become a promising target in the treatment of B-NHL.
Annotations
External Annotation for MCM3AP-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
