Basic Information
Regular Relationship :
Tissue/Cell lineThe human ovarian cancer cell lines SKOV3 (human ovarian adenocarcinoma cells), ES2 (human ovarian clear cell carcinoma cells), and OVCAR3 (human ovarian adenocarcinoma cells)
SpecieHomo sapiens (human)
CitationExp Cell Res 2020 Oct 15 395, 112218 doi:10.1016/j.yexcr.2020.112218 PMID:32771526
Reference title
HOTAIR maintains the stemness of ovarian cancer stem cells via the miR-206/TBX3 axis.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay etc.
Functional description
Collectively, this study highlights a role of HOTAIR in the stemness maintenance of OCSCs. HOTAIR could serve as a miR-206 sponge, causing the up-regulated expression of TBX3 to promote the stemness of OCSCs. Identification of the HOTAIR/miR-206/TBX3 axis provides new insight into the molecular mechanisms underlying the regulation and maintenance of OCSCs, which might help to improve lncRNA-targeted diagnosis and treatment strategies for ovarian cancer.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
